Version 5.4
Homo sapiens Protein: TWISTNB
Summary
InnateDB Protein IDBP-9131.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TWISTNB
Protein Name TWIST neighbor
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000222567
InnateDB Gene IDBG-9129 (TWISTNB)
Protein Structure
UniProt Annotation
Function DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Through its association with RRN3/TIF-IA may be involved in recruitment of Pol I to rDNA promoters.
Subcellular Localization Nucleus, nucleolus {ECO:0000250}.
Disease Associations
Tissue Specificity Widely expressed. Expressed in all fetal and adult tissues tested, with highest expression in fetal lung, liver, and kidney, and low expression in all adult tissues. {ECO:0000269PubMed:12438708}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001054 RNA polymerase I activity
GO:0003899 DNA-directed RNA polymerase activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006360 transcription from RNA polymerase I promoter
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005736 DNA-directed RNA polymerase I complex
GO:0015630 microtubule cytoskeleton
Protein Structure and Domains
PDB ID
InterPro IPR005576 RNA polymerase Rpb7, N-terminal
PFAM PF03876
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3B726
PhosphoSite PhosphoSite-Q3B726
TrEMBL
UniProt Splice Variant
Entrez Gene 221830
UniGene Hs.701612
RefSeq NP_001002926
HUGO HGNC:18027
OMIM 608312
CCDS CCDS34606
HPRD 16311
IMGT
EMBL AK301329 BC014574 BC130298 BC130300 BK000492 CH236948 CH471073
GenPept AAH14574 AAI30299 AAI30301 BAH13460 DAA05732 EAL24277 EAW93714

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca