InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC2A6

Summary

InnateDB Protein

IDBP-91442.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC2A6

Protein Name

solute carrier family 2 (facilitated glucose transporter), member 6

Synonyms

GLUT6; GLUT9; HSA011372;

Species

Homo sapiens

Ensembl Protein

ENSP00000360966

InnateDB Gene

IDBG-91438 (SLC2A6)

Protein Structure

UniProt Annotation

Function

Facilitative glucose transporter; binds cytochalasin B with low affinity.

Subcellular Localization

Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=The dileucine internalization motif is critical for intracellular sequestration. {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in brain, spleen and peripheral blood leukocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005355	glucose transmembrane transporter activity
GO:0022857	transmembrane transporter activity
GO:0022891	substrate-specific transmembrane transporter activity

Biological Process

GO:0015758	glucose transport
GO:0055085	transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR003663 Sugar/inositol transporter
IPR005828 General substrate transporter
IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR020846 Major facilitator superfamily domain

PFAM

PF00083
PF07690

PRINTS

PR00171

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9UGQ3