Homo sapiens Protein: FBXO42
Summary
InnateDB Protein IDBP-91461.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FBXO42
Protein Name F-box protein 42
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000364742
InnateDB Gene IDBG-91459 (FBXO42)
Protein Structure
UniProt Annotation
Function Substrate-recognition component of some SCF (SKP1-CUL1- F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation. {ECO:0000269PubMed:19509332}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR001810 F-box domain
IPR006652 Kelch repeat type 1
IPR011498 Kelch repeat type 2
PFAM PF00646
PF12937
PF13013
PF01344
PF07646
PRINTS
PIRSF
SMART SM00256
SM00612
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6P3S6
PhosphoSite PhosphoSite-Q6P3S6
TrEMBL A0A024QZB0
UniProt Splice Variant
Entrez Gene 54455
UniGene Hs.642443
RefSeq NP_061867
HUGO HGNC:29249
OMIM 609109
CCDS CCDS30613
HPRD
IMGT
EMBL AB037753 AK055598 AL109627 AL358794 AL833874 BC006174 BC032439 BC043410 BC063864 CH471167
GenPept AAH06174 AAH32439 AAH43410 AAH63864 BAA92570 BAG51542 CAD38731 CAH73774 CAI22560 CAI22561 EAW51774 EAW51775