InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SARDH

Summary

InnateDB Protein

IDBP-91538.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SARDH

Protein Name

sarcosine dehydrogenase

Synonyms

BPR-2; DMGDHL1; SAR; SARD; SDH;

Species

Homo sapiens

Ensembl Protein

ENSP00000360938

InnateDB Gene

IDBG-91536 (SARDH)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Mitochondrion matrix {ECO:0000250}.

Disease Associations

Sarcosinemia (SARCOS) [MIM:268900]: A metabolic disorder characterized by an increased concentration of sarcosine in plasma and an increased excretion of sarcosine in urine. Sarcosinemia is most probably a benign condition without significant clinical problems. Some reports have associated sarcosinemia with mental retardation and neurologic problems. {ECO:0000269PubMed:10444331, ECO:0000269PubMed:22825317}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004047	aminomethyltransferase activity
GO:0008480	sarcosine dehydrogenase activity
GO:0016491	oxidoreductase activity

Biological Process

GO:0006546	glycine catabolic process
GO:0032259	methylation
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix

Protein Structure and Domains

PDB ID

InterPro

IPR006076 FAD dependent oxidoreductase
IPR006222 Glycine cleavage T-protein, N-terminal
IPR013977 Glycine cleavage T-protein, C-terminal barrel domain
IPR029043 Glycine cleavage T-protein/YgfZ, C-terminal domain

PFAM

PF01266
PF01571
PF08669

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9UL12

PhosphoSite