InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ATE1

Summary

InnateDB Protein

IDBP-91603.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATE1

Protein Name

arginyltransferase 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000224652

InnateDB Gene

IDBG-91597 (ATE1)

Protein Structure

UniProt Annotation

Function

Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Does not arginylate cysteine residues (By similarity). {ECO:0000250}.

Subcellular Localization

Isoform ATE1-1: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.Isoform ATE1-2: Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004057	arginyltransferase activity
GO:0005515	protein binding

Biological Process

GO:0016598

protein arginylation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR007471 Arginine-tRNA-protein transferase, N-terminal
IPR007472 Arginine-tRNA-protein transferase, C-terminal
IPR016181 Acyl-CoA N-acyltransferase
IPR017137 Arginine-tRNA-protein transferase 1, eukaryotic

PFAM

PF04376
PF04377

PRINTS

PIRSF

PIRSF037207

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O95260