InnateDB Protein
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IDBP-91611.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CROCC
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Protein Name
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ciliary rootlet coiled-coil, rootletin
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Synonyms
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ROLT;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000364691
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InnateDB Gene
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IDBG-91607 (CROCC)
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Protein Structure
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Function |
Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus. Contributes to centrosome cohesion before mitosis. {ECO:0000250UniProtKB:Q8CJ40, ECO:0000269PubMed:16203858}.
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Subcellular Localization |
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269PubMed:14654843}. Note=In ciliated cells, associated with ciliary rootlets. In non-ciliated cells, localized between, around and at the proximal ends of the centrioles. Dissociates from the centrioles at the onset of mitosis and reassociates with them at anaphase.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
6
[view]
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Protein-Protein |
6
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR009053
Prefoldin
IPR010989
t-SNARE
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q5TZA2
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PhosphoSite |
PhosphoSite-Q5TZA2
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
9696
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UniGene |
Hs.309403
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RefSeq |
NP_055490
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HUGO |
HGNC:21299
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OMIM |
615776
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CCDS |
CCDS30616
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HPRD |
16758
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IMGT |
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EMBL |
AB007914
AF527734
AL049569
BK005505
BX284668
DQ139275
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GenPept |
AAP85633
ABA43896
BAA32290
CAH70055
CAI20363
DAA05505
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