InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PDIA3

Summary

InnateDB Protein

IDBP-9162.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDIA3

Protein Name

protein disulfide isomerase family A, member 3

Synonyms

ER60; ERp57; ERp60; ERp61; GRP57; GRP58; HEL-S-269; HEL-S-93n; HsT17083; P58; PI-PLC;

Species

Homo sapiens

Ensembl Protein

ENSP00000300289

InnateDB Gene

IDBG-9160 (PDIA3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Endoplasmic reticulum. Endoplasmic reticulum lumen {ECO:0000250}. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Disease Associations

Tissue Specificity

Detected in the flagellum and head region of spermatozoa (at protein level). {ECO:0000269PubMed:20400973}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 125 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	125 [view]
Protein-Protein	125 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003756	protein disulfide isomerase activity
GO:0004197	cysteine-type endopeptidase activity
GO:0004629	phospholipase C activity
GO:0005515	protein binding
GO:0016853	isomerase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0006457	protein folding
GO:0006508	proteolysis
GO:0006606	protein import into nucleus
GO:0006621	protein retention in ER lumen
GO:0007165	signal transduction
GO:0018279	protein N-linked glycosylation via asparagine
GO:0034976	response to endoplasmic reticulum stress
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process
GO:0045454	cell redox homeostasis
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005783	endoplasmic reticulum
GO:0005788	endoplasmic reticulum lumen
GO:0005790	smooth endoplasmic reticulum
GO:0009986	cell surface
GO:0042470	melanosome
GO:0070062	extracellular vesicular exosome