InnateDB Protein
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IDBP-91628.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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LAGE3
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Protein Name
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L antigen family, member 3
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Synonyms
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CVG5; DXS9879E; DXS9951E; ESO3; ITBA2;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000349923
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InnateDB Gene
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IDBG-91626 (LAGE3)
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Protein Structure
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Function |
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. LAGE3 functions as a dimerization module for the complex (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:22912744}.
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Disease Associations |
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Tissue Specificity |
Ubiquitous. {ECO:0000269PubMed:12384295, ECO:0000269PubMed:8786131}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
38
[view]
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Protein-Protein |
35
[view]
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Protein-DNA |
3
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR015419
EKC/KEOPS complex, subunit Pcc1
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PFAM |
PF09341
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q14657
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PhosphoSite |
PhosphoSite-Q14657
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TrEMBL |
B0S8I7
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UniProt Splice Variant |
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Entrez Gene |
8270
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UniGene |
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RefSeq |
NP_006005
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HUGO |
HGNC:26058
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OMIM |
300060
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CCDS |
CCDS14753
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HPRD |
02087
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IMGT |
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EMBL |
BC015744
BC062330
BX936365
X92896
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GenPept |
AAH15744
AAH62330
CAA63489
CAI43195
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