InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KHDRBS2

Summary

InnateDB Protein

IDBP-91642.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KHDRBS2

Protein Name

KH domain containing, RNA binding, signal transduction associated 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000281156

InnateDB Gene

IDBG-91640 (KHDRBS2)

Protein Structure

UniProt Annotation

Function

RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Its phosphorylation by FYN inhibits its ability to regulate splice site selection. Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. May function as an adapter protein for Src kinases during mitosis. Binds both poly(A) and poly(U) homopolymers. Phosphorylation by PTK6 inhibits its RNA-binding ability (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in brain, lung, kidney and small intestine. Weakly expressed in placenta, liver, spleen, thymus, ovary and colon. {ECO:0000269PubMed:12549823}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 56 experimentally validated interaction(s) in this database.

Experimentally validated
Total	56 [view]
Protein-Protein	55 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0008143	poly(A) binding
GO:0008266	poly(U) RNA binding
GO:0017124	SH3 domain binding
GO:0042169	SH2 domain binding
GO:0046982	protein heterodimerization activity