Version 5.4
Homo sapiens Protein: UBL4A
Summary
InnateDB Protein IDBP-91650.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UBL4A
Protein Name ubiquitin-like 4A
Synonyms DX254E; DXS254E; G6PD; GDX; GET5; MDY2; TMA24; UBL4;
Species Homo sapiens
Ensembl Protein ENSP00000358674
InnateDB Gene IDBG-91648 (UBL4A)
Protein Structure
UniProt Annotation
Function Component of the BAT3 complex, a multiprotein complex involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane. TA membrane proteins, also named type II transmembrane proteins, contain a single C-terminal transmembrane region. The complex acts by facilitating TA proteins capture by ASNA1/TRC40: it is recruited to ribosomes synthesizing membrane proteins, interacts with the transmembrane region of newly released TA proteins, and transfers them to ASNA1/TRC40 for targeting. {ECO:0000269PubMed:20676083}.
Subcellular Localization Cytoplasm, cytosol {ECO:0000269PubMed:20676083}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 280 experimentally validated interaction(s) in this database.
Experimentally validated
Total 280 [view]
Protein-Protein 280 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019787 small conjugating protein ligase activity
Biological Process
GO:0006464 cellular protein modification process
GO:0006810 transport
GO:0071816 tail-anchored membrane protein insertion into ER membrane
Cellular Component
GO:0005829 cytosol
GO:0071818 BAT3 complex
Protein Structure and Domains
PDB ID
InterPro IPR000626 Ubiquitin-like
IPR019956 Ubiquitin
IPR022617 Rad60/SUMO-like domain
IPR029071 Ubiquitin-related domain
PFAM PF00240
PF14560
PF11976
PRINTS PR00348
PIRSF
SMART SM00213
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P11441
PhosphoSite PhosphoSite-P11441
TrEMBL
UniProt Splice Variant
Entrez Gene 8266
UniGene Hs.76480
RefSeq NP_055050
HUGO HGNC:12505
OMIM 312070
CCDS CCDS14754
HPRD 02417
IMGT
EMBL BC043346 BC053589 BX664739 CH471172 J03589 L44140
GenPept AAA36790 AAA92650 AAH43346 AAH53589 CAI43235 EAW72700

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca