InnateDB Protein
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IDBP-91675.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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BRD3
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Protein Name
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bromodomain containing 3
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Synonyms
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ORFX; RING3L;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000305918
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InnateDB Gene
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IDBG-91671 (BRD3)
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Protein Structure
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Function |
Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors. Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity). Regulates transcription of the CCND1 gene. {ECO:0000250, ECO:0000269PubMed:18406326}.
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Subcellular Localization |
Nucleus {ECO:0000305}. Note=Detected on chromatin. {ECO:0000250}.
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Disease Associations |
Note=A chromosomal aberration involving BRD3 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;9)(q14;q34) with NUT which produces a BRD3-NUT fusion protein.
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Tissue Specificity |
Ubiquitous.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
11
[view]
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Protein-Protein |
11
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001487
Bromodomain
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PFAM |
PF00439
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PRINTS |
PR00503
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PIRSF |
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SMART |
SM00297
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TIGRFAMs |
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Modification |
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SwissProt |
Q15059
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PhosphoSite |
PhosphoSite-Q15059
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TrEMBL |
B4DS09
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UniProt Splice Variant |
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Entrez Gene |
8019
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UniGene |
Hs.522472
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RefSeq |
NP_031397
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HUGO |
HGNC:1104
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OMIM |
601541
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CCDS |
CCDS6980
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HPRD |
03327
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IMGT |
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EMBL |
AK299519
AL445931
AL591386
AY513270
BC032124
CH471090
D26362
Z81330
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GenPept |
AAH32124
AAS82952
BAA05393
BAG61471
CAI13726
CAI13727
EAW88113
EAW88114
EAW88115
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