Version 5.4
Homo sapiens Protein: BRD3
Summary
InnateDB Protein IDBP-91679.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BRD3
Protein Name bromodomain containing 3
Synonyms ORFX; RING3L;
Species Homo sapiens
Ensembl Protein ENSP00000360900
InnateDB Gene IDBG-91671 (BRD3)
Protein Structure
UniProt Annotation
Function Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors. Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity). Regulates transcription of the CCND1 gene. {ECO:0000250, ECO:0000269PubMed:18406326}.
Subcellular Localization Nucleus {ECO:0000305}. Note=Detected on chromatin. {ECO:0000250}.
Disease Associations Note=A chromosomal aberration involving BRD3 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;9)(q14;q34) with NUT which produces a BRD3-NUT fusion protein.
Tissue Specificity Ubiquitous.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0070577 lysine-acetylated histone binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0016568 chromatin modification
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR001487 Bromodomain
PFAM PF00439
PRINTS PR00503
PIRSF
SMART SM00297
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q15059
PhosphoSite PhosphoSite-Q15059
TrEMBL A9J575
UniProt Splice Variant
Entrez Gene 8019
UniGene Hs.522472
RefSeq
HUGO HGNC:1104
OMIM 601541
CCDS
HPRD 03327
IMGT
EMBL AL445931 AL591386 AY513270 BC032124 CH471090 D26362 Z81330
GenPept AAH32124 AAS82952 BAA05393 CAI13726 CAI13727 EAW88113 EAW88114

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca