Version 5.4
Homo sapiens Protein: LGSN
Summary
InnateDB Protein IDBP-91684.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LGSN
Protein Name lengsin, lens protein with glutamine synthetase domain
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000359692
InnateDB Gene IDBG-91682 (LGSN)
Protein Structure
UniProt Annotation
Function May act as a component of the cytoskeleton or as a chaperone for the reorganization of intermediate filament proteins during terminal differentiation in the lens. Does not seem to have enzymatic activity (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity Abundantly expressed in lens. {ECO:0000269PubMed:12107413, ECO:0000269PubMed:17010935}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004356 glutamate-ammonia ligase activity
Biological Process
GO:0006542 glutamine biosynthetic process
GO:0006807 nitrogen compound metabolic process
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR008147 Glutamine synthetase, beta-Grasp
PFAM PF03951
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5TDP6
PhosphoSite PhosphoSite-Q5TDP6
TrEMBL
UniProt Splice Variant
Entrez Gene 51557
UniGene Hs.609918
RefSeq NP_001137412
HUGO HGNC:21016
OMIM 611470
CCDS CCDS55027
HPRD 13585
IMGT
EMBL AF242388 AL121949 AL590456 BC130366 BC130368 CH471143 DQ682605 DQ682606
GenPept AAF61255 AAI30367 AAI30369 ABG75902 ABG75903 CAI20481 EAW88493

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca