InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ITGB8

Summary

InnateDB Protein

IDBP-9183.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ITGB8

Protein Name

integrin, beta 8

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000222573

InnateDB Gene

IDBG-9181 (ITGB8)

Protein Structure

UniProt Annotation

Function

Integrin alpha-V/beta-8 is a receptor for fibronectin.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Placenta, kidney, brain, ovary, uterus and in several transformed cells. Transiently expressed in 293 human embryonic kidney cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005102	receptor binding

Biological Process

GO:0001573	ganglioside metabolic process
GO:0007155	cell adhesion
GO:0007160	cell-matrix adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0007275	multicellular organismal development
GO:0030198	extracellular matrix organization
GO:0060674	placenta blood vessel development

Cellular Component

GO:0005886	plasma membrane
GO:0008305	integrin complex
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR002035 von Willebrand factor, type A
IPR002369 Integrin beta subunit, N-terminal
IPR013111 EGF-like domain, extracellular
IPR015812 Integrin beta subunit
IPR016201 Plexin-like fold

PFAM

PF00092
PF00362
PF07974

PRINTS

PR01186

PIRSF

PIRSF002512

SMART

SM00327
SM00187
SM00423

TIGRFAMs

Post-translational Modifications

Modification

Cross-References