InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MAPK8IP3

Summary

InnateDB Protein

IDBP-9186.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAPK8IP3

Protein Name

mitogen-activated protein kinase 8 interacting protein 3

Synonyms

JIP3; JSAP1; syd; SYD2;

Species

Homo sapiens

Ensembl Protein

ENSP00000250894

InnateDB Gene

IDBG-9184 (MAPK8IP3)

Protein Structure

UniProt Annotation

Function

The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	32 [view]
Protein-Protein	31 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005078	MAP-kinase scaffold activity
GO:0005515	protein binding
GO:0008432	JUN kinase binding
GO:0019894	kinesin binding
GO:0019901	protein kinase binding
GO:0031434	mitogen-activated protein kinase kinase binding
GO:0031435	mitogen-activated protein kinase kinase kinase binding

Biological Process

GO:0001701	in utero embryonic development
GO:0007254	JNK cascade
GO:0007257	activation of JUN kinase activity
GO:0007411	axon guidance
GO:0007585	respiratory gaseous exchange
GO:0008104	protein localization
GO:0009791	post-embryonic development
GO:0010468	regulation of gene expression
GO:0016192	vesicle-mediated transport
GO:0030900	forebrain development
GO:0031175	neuron projection development
GO:0043507	positive regulation of JUN kinase activity
GO:0045666	positive regulation of neuron differentiation
GO:0046328	regulation of JNK cascade
GO:0048286	lung alveolus development
GO:0060425	lung morphogenesis

Cellular Component

GO:0000139	Golgi membrane
GO:0005737	cytoplasm
GO:0005790	smooth endoplasmic reticulum
GO:0005886	plasma membrane
GO:0030425	dendrite
GO:0030673	axolemma
GO:0043005	neuron projection