InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PLEKHA1

Summary

InnateDB Protein

IDBP-91881.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLEKHA1

Protein Name

pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000357986

InnateDB Gene

IDBG-91879 (PLEKHA1)

Protein Structure

UniProt Annotation

Function

Binds specifically to phosphatidylinositol 3,4- diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane. {ECO:0000269PubMed:11001876, ECO:0000269PubMed:11513726, ECO:0000269PubMed:14516276}.

Subcellular Localization

Cytoplasm. Cell membrane; Peripheral membrane protein. Nucleus. Note=Locates to the plasma membrane after treatments that stimulate the production of PtdIns3,4P2.

Disease Associations

Tissue Specificity

Highly expressed in skeletal muscle, thymus, pancreas, placenta and lung. Detected at low levels in brain, heart, peripheral blood leukocytes, testis, ovary, spinal cord, thyroid, kidney, liver, small intestine and colon. {ECO:0000269PubMed:11001876, ECO:0000269PubMed:12101241}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0030165	PDZ domain binding
GO:0043325	phosphatidylinositol-3,4-bisphosphate binding

Biological Process

GO:0001553	luteinization
GO:0007283	spermatogenesis
GO:0008209	androgen metabolic process
GO:0008210	estrogen metabolic process
GO:0008585	female gonad development
GO:0009791	post-embryonic development
GO:0014065	phosphatidylinositol 3-kinase signaling
GO:0031529	ruffle organization
GO:0033327	Leydig cell differentiation
GO:0035264	multicellular organism growth
GO:0045184	establishment of protein localization
GO:0048008	platelet-derived growth factor receptor signaling pathway
GO:0048705	skeletal system morphogenesis
GO:0050853	B cell receptor signaling pathway
GO:0051898	negative regulation of protein kinase B signaling
GO:0060021	palate development
GO:0060325	face morphogenesis
GO:0070301	cellular response to hydrogen peroxide