Version 5.4
Homo sapiens Protein: PHF5A
Summary
InnateDB Protein IDBP-9196.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PHF5A
Protein Name PHD finger protein 5A
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000216252
InnateDB Gene IDBG-9194 (PHF5A)
Protein Structure
UniProt Annotation
Function Acts as a transcriptional regulator by binding to the GJA1/Cx43 promoter and enhancing its up-regulation by ESR1/ER- alpha. Also involved in pre-mRNA splicing. {ECO:0000269PubMed:12234937}.
Subcellular Localization Nucleus {ECO:0000250}. Nucleus speckle {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
Experimentally validated
Total 36 [view]
Protein-Protein 35 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006351 transcription, DNA-templated
GO:0008380 RNA splicing
GO:0010467 gene expression
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0005654 nucleoplasm
GO:0005686 U2 snRNP
GO:0005689 U12-type spliceosomal complex
GO:0016363 nuclear matrix
GO:0016607 nuclear speck
Protein Structure and Domains
PDB ID
InterPro IPR005345 PHF5-like
PFAM PF03660
PRINTS
PIRSF PIRSF016468
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7RTV0
PhosphoSite PhosphoSite-Q7RTV0
TrEMBL A0A024R1U2
UniProt Splice Variant
Entrez Gene 84844
UniGene Hs.707800
RefSeq NP_116147
HUGO HGNC:18000
OMIM
CCDS CCDS14016
HPRD 15126
IMGT
EMBL AL008582 BC007321 BC075808 BK000563 CH471095 CR456398
GenPept AAH07321 AAH75808 CAB62939 CAG30284 DAA00074 EAW60433 EAW60434

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca