InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TAS1R2

Summary

InnateDB Protein

IDBP-92038.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TAS1R2

Protein Name

taste receptor, type 1, member 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000364520

InnateDB Gene

IDBG-92036 (TAS1R2)

Protein Structure

UniProt Annotation

Function

Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0008527	taste receptor activity
GO:0033041	sweet taste receptor activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001582	detection of chemical stimulus involved in sensory perception of sweet taste
GO:0007186	G-protein coupled receptor signaling pathway
GO:0032467	positive regulation of cytokinesis
GO:0050916	sensory perception of sweet taste

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0043235	receptor complex

Protein Structure and Domains

PDB ID

InterPro

IPR000337 GPCR, family 3
IPR001828 Extracellular ligand-binding receptor
IPR011500 GPCR, family 3, nine cysteines domain
IPR017978 GPCR, family 3, C-terminal
IPR028082 Periplasmic binding protein-like I

PFAM

PF01094
PF07562
PF00003

PRINTS

PR00248

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8TE23