Version 5.4
Homo sapiens Protein: SOHLH1
Summary
InnateDB Protein IDBP-92096.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SOHLH1
Protein Name spermatogenesis and oogenesis specific basic helix-loop-helix 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000298466
InnateDB Gene IDBG-92094 (SOHLH1)
Protein Structure
UniProt Annotation
Function Transcription factor expressed in undifferentiated spermatogonia required for spermatogonial development. {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000255PROSITE-ProRule:PRU00981}.
Disease Associations Note=Genetic variations in SOHLH1 may be associated with non-obstructive azoospermia.
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0046983 protein dimerization activity
Biological Process
GO:0006351 transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
PFAM PF00010
PRINTS
PIRSF
SMART SM00353
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5JUK2
PhosphoSite PhosphoSite-Q5JUK2
TrEMBL
UniProt Splice Variant
Entrez Gene 402381
UniGene Hs.120464
RefSeq NP_001012415
HUGO HGNC:27845
OMIM 610224
CCDS CCDS35174
HPRD 16678
IMGT
EMBL AL158822 AY884306 AY902244 BC031861 CH471090 DB304976
GenPept AAH31861 AAW78548 AAW82617 CAI39241 EAW88175

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca