InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LHX3

Summary

InnateDB Protein

IDBP-92195.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LHX3

Protein Name

LIM homeobox 3

Synonyms

CPHD3; LIM3; M2-LHX3;

Species

Homo sapiens

Ensembl Protein

ENSP00000360811

InnateDB Gene

IDBG-92191 (LHX3)

Protein Structure

UniProt Annotation

Function

Acts as a transcriptional activator. Binds to and activates the promoter of the alpha-glycoprotein gene, and synergistically enhances transcription from the prolactin promoter in cooperation with POU1F1/Pit-1 (By similarity). Required for the establishment of the specialized cells of the pituitary gland and the nervous system. Involved in the development of interneurons and motor neurons in cooperation with LDB1 and ISL1. {ECO:0000250, ECO:0000269PubMed:21149718}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Pituitary hormone deficiency, combined, 3 (CPHD3) [MIM:221750]: Combined pituitary hormone deficiency is defined as the impaired production of growth hormone and one or more of the other five anterior pituitary hormones. CPHD3 is characterized by a complete deficit in all but one (adrenocorticotropin) anterior pituitary hormone and a rigid cervical spine leading to limited head rotation. {ECO:0000269PubMed:10835633, ECO:0000269PubMed:17327381}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001076	RNA polymerase II transcription factor binding transcription factor activity
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001890	placenta development
GO:0006366	transcription from RNA polymerase II promoter
GO:0008045	motor neuron axon guidance
GO:0009887	organ morphogenesis
GO:0009953	dorsal/ventral pattern formation
GO:0021520	spinal cord motor neuron cell fate specification
GO:0021521	ventral spinal cord interneuron specification
GO:0021526	medial motor column neuron differentiation
GO:0021527	spinal cord association neuron differentiation
GO:0021983	pituitary gland development
GO:0030154	cell differentiation
GO:0030324	lung development
GO:0043066	negative regulation of apoptotic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048839	inner ear development