Version 5.4
Homo sapiens Protein: PLEKHG3
Summary
InnateDB Protein IDBP-9223.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLEKHG3
Protein Name pleckstrin homology domain containing, family G (with RhoGef domain) member 3
Synonyms ARHGEF43; KIAA0599;
Species Homo sapiens
Ensembl Protein ENSP00000247226
InnateDB Gene IDBG-9221 (PLEKHG3)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005089 Rho guanyl-nucleotide exchange factor activity
Biological Process
GO:0032321 positive regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR000219 Dbl homology (DH) domain
IPR001849 Pleckstrin homology domain
PFAM PF00621
PF00169
PRINTS
PIRSF
SMART SM00325
SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A1L390
PhosphoSite PhosphoSite-AAH04298
TrEMBL G3V311
UniProt Splice Variant
Entrez Gene 26030
UniGene Hs.689614
RefSeq NP_056364
HUGO HGNC:20364
OMIM
CCDS CCDS32098
HPRD 17861
IMGT
EMBL AB011171 AK074169 AL121774 BC004298 BC011891 BC063554 BC073907 BC129952 BC129953 BX248779
GenPept AAH04298 AAH11891 AAH63554 AAH73907 AAI29953 AAI29954 BAA25525 BAB84995 CAD66586

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca