Version 5.4
Homo sapiens Protein: CUZD1
Summary
InnateDB Protein IDBP-92235.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CUZD1
Protein Name CUB and zona pellucida-like domains 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000357900
InnateDB Gene IDBG-92233 (CUZD1)
Protein Structure
UniProt Annotation
Function CUZD1 antiserum inhibits cell attachment and proliferation of ovarian cancer cells so may be involved in these processes. May also play a role in the uterus during late pregnancy and/or in trypsin activation in pancreatic acinar cells. {ECO:0000250UniProtKB:P70412, ECO:0000269PubMed:15184879}.
Subcellular Localization Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Associated with zymogen granule membranes. {ECO:0000250}.
Disease Associations
Tissue Specificity Detected in pancreas and epithelium of ovary. Expressed at higher levels in ovarian tumors than in normal tissue. {ECO:0000269PubMed:15184879}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006931 substrate-dependent cell migration, cell attachment to substrate
GO:0007049 cell cycle
GO:0008283 cell proliferation
GO:0032023 trypsinogen activation
GO:0051301 cell division
Cellular Component
GO:0016021 integral component of membrane
GO:0030658 transport vesicle membrane
GO:0042588 zymogen granule
GO:0042589 zymogen granule membrane
Protein Structure and Domains
PDB ID
InterPro IPR000859 CUB domain
IPR001507 Zona pellucida domain
PFAM PF00431
PF00100
PRINTS PR00023
PIRSF
SMART SM00042
SM00241
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q86UP6
PhosphoSite PhosphoSite-Q86UP6
TrEMBL
UniProt Splice Variant
Entrez Gene 50624
UniGene Hs.647182
RefSeq
HUGO HGNC:17937
OMIM
CCDS CCDS7631
HPRD 06476
IMGT
EMBL AC073585 AF305835 AK289445 AL359747 AY260047 AY260048 AY260049 AY260050 AY358556 BC136755 BX538283 BX538284 CH471066
GenPept AAG23215 AAI36756 AAP15458 AAP15459 AAP15460 AAP15461 AAQ88920 BAF82134 CAD98079 CAD98080 CAH70003 CAH70004 CAH70006 EAW49302 EAW49303 EAW49304 EAW49305

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca