InnateDB Protein
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IDBP-92337.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SNAPC4
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Protein Name
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small nuclear RNA activating complex, polypeptide 4, 190kDa
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Synonyms
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PTFalpha; SNAP190;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000298532
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InnateDB Gene
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IDBG-92335 (SNAPC4)
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Protein Structure
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Function |
Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. {ECO:0000269PubMed:12621023, ECO:0000269PubMed:9418884}.
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Subcellular Localization |
Nucleus {ECO:0000255PROSITE- ProRule:PRU00625}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
14
[view]
|
Protein-Protein |
14
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
GO:0006355
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regulation of transcription, DNA-templated
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GO:0006366
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transcription from RNA polymerase II promoter
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GO:0006383
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transcription from RNA polymerase III promoter
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GO:0009301
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snRNA transcription
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GO:0010467
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gene expression
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GO:0042795
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snRNA transcription from RNA polymerase II promoter
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GO:0042796
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snRNA transcription from RNA polymerase III promoter
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Cellular Component |
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PDB ID |
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InterPro |
IPR001005
SANT/Myb domain
IPR009057
Homeodomain-like
IPR017877
Myb-like domain
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PFAM |
PF00249
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PRINTS |
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PIRSF |
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SMART |
SM00717
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TIGRFAMs |
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Modification |
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SwissProt |
Q5SXM2
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PhosphoSite |
PhosphoSite-Q5SXM2
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TrEMBL |
A0A024R8F4
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UniProt Splice Variant |
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Entrez Gene |
6621
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UniGene |
Hs.113265
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RefSeq |
NP_003077
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HUGO |
HGNC:11137
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OMIM |
602777
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CCDS |
CCDS6998
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HPRD |
04146
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IMGT |
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EMBL |
AF032387
AL592301
CH471090
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GenPept |
AAC02972
CAI13935
EAW88225
EAW88226
EAW88227
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