Version 5.4
Homo sapiens Protein: IKZF5
Summary
InnateDB Protein IDBP-92367.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IKZF5
Protein Name IKAROS family zinc finger 5 (Pegasus)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000357881
InnateDB Gene IDBG-92365 (IKZF5)
Protein Structure
UniProt Annotation
Function DNA-binding protein that binds to the 5'GNNTGTNG-3' core sequence. Transcriptional repressor. {ECO:0000269PubMed:10978333}.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed in brain, heart, skeletal muscle, kidney, and liver. Expressed in the hematopoietic cell lines MOLT- 4, NALM-6 and K-562. Highly expressed in THP-1 and M-07e cell lines, which have characteristics of myeloid and early megakaryocytic cells respectively. {ECO:0000269PubMed:10978333}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR007087 Zinc finger, C2H2
IPR015880 Zinc finger, C2H2-like
PFAM PF00096
PRINTS
PIRSF
SMART SM00355
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H5V7
PhosphoSite PhosphoSite-Q9H5V7
TrEMBL
UniProt Splice Variant
Entrez Gene 64376
UniGene Hs.707006
RefSeq XP_006718010
HUGO HGNC:14283
OMIM 606238
CCDS CCDS41574
HPRD 05873
IMGT
EMBL AF230808 AK026626 AK122899 BX647958 CH471066 CR749800
GenPept AAG39220 BAB15512 BAG53789 CAH18660 CAH56199 EAW49292 EAW49293 EAW49294

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca