Version 5.4
Homo sapiens Protein: HMX2
Summary
InnateDB Protein IDBP-92473.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HMX2
Protein Name H6 family homeobox 2
Synonyms H6L; Nkx5-2;
Species Homo sapiens
Ensembl Protein ENSP00000341108
InnateDB Gene IDBG-92471 (HMX2)
Protein Structure
UniProt Annotation
Function Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000255PROSITE- ProRule:PRU00108}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007420 brain development
GO:0008284 positive regulation of cell proliferation
GO:0030154 cell differentiation
GO:0042472 inner ear morphogenesis
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR001356 Homeobox domain
IPR009057 Homeodomain-like
IPR020479 Homeodomain, metazoa
PFAM PF00046
PRINTS PR00024
PIRSF
SMART SM00389
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A2RU54
PhosphoSite PhosphoSite-A2RU54
TrEMBL
UniProt Splice Variant
Entrez Gene 3167
UniGene Hs.444756
RefSeq NP_005510
HUGO HGNC:5018
OMIM 600647
CCDS CCDS31305
HPRD 18780
IMGT
EMBL BC132758 BC137139 CH471066
GenPept AAI32759 AAI37140 EAW49288

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca