Version 5.4
Homo sapiens Protein: AKR7A3
Summary
InnateDB Protein IDBP-92521.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AKR7A3
Protein Name aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
Synonyms AFAR2;
Species Homo sapiens
Ensembl Protein ENSP00000355377
InnateDB Gene IDBG-92519 (AKR7A3)
Protein Structure
UniProt Annotation
Function Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen. {ECO:0000269PubMed:18416522}.
Subcellular Localization Cytoplasm.
Disease Associations
Tissue Specificity Expressed in colon, kidney, liver, pancreas, adenocarcinoma and endometrium. {ECO:0000269PubMed:12879023, ECO:0000269PubMed:18416522}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004033 aldo-keto reductase (NADP) activity
GO:0009055 electron carrier activity
Biological Process
GO:0006081 cellular aldehyde metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR023210 NADP-dependent oxidoreductase domain
PFAM PF00248
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O95154
PhosphoSite PhosphoSite-O95154
TrEMBL
UniProt Splice Variant
Entrez Gene 22977
UniGene Hs.6980
RefSeq NP_036199
HUGO HGNC:390
OMIM 608477
CCDS CCDS193
HPRD 07089
IMGT
EMBL AF040639 AJ271799 AL035413 BC025709 BC031562 BC042420
GenPept AAD02195 AAH25709 AAH31562 AAH42420 CAC81076 CAI22232

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca