InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AKR7A2

Summary

InnateDB Protein

IDBP-92537.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AKR7A2

Protein Name

aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)

Synonyms

AFAR; AFAR1; AFB1-AR1; AKR7;

Species

Homo sapiens

Ensembl Protein

ENSP00000235835

InnateDB Gene

IDBG-92533 (AKR7A2)

Protein Structure

UniProt Annotation

Function

Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2- nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen. {ECO:0000269PubMed:17591773, ECO:0000269PubMed:9576847}.

Subcellular Localization

Golgi apparatus {ECO:0000250}. Cytoplasm {ECO:0000269PubMed:9576847}.

Disease Associations

Tissue Specificity

Detected in brain, liver, small intestine and testis, and at lower levels in heart, prostate, skeletal muscle and spleen. Detected in kidney proximal and distal tubules, endothelial cells lining the Bowman's capsules and some cysts. Detected at low levels in lung and pancreas (at protein level). Widely expressed. {ECO:0000269PubMed:10510318, ECO:0000269PubMed:9576847}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	5 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004032	alditol:NADP+ 1-oxidoreductase activity
GO:0009055	electron carrier activity
GO:0019119	phenanthrene-9,10-epoxide hydrolase activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006081	cellular aldehyde metabolic process
GO:0044597	daunorubicin metabolic process
GO:0044598	doxorubicin metabolic process
GO:0055114	oxidation-reduction process