InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GPR26

Summary

InnateDB Protein

IDBP-92569.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GPR26

Protein Name

G protein-coupled receptor 26

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000284674

InnateDB Gene

IDBG-92567 (GPR26)

Protein Structure

UniProt Annotation

Function

Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. {ECO:0000269PubMed:17363172}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Highly expressed in the CNS, the highest expression is seen in the amygdala, hippocampus and thalamus. Weak expression is detected in testis. Down-regulated in glioblastoma. {ECO:0000269PubMed:17363172, ECO:0000269PubMed:18037267}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019427 7TM GPCR, serpentine receptor class w (Srw)

PFAM

PF00001
PF10320
PF10324

PRINTS

PR00237

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8NDV2