InnateDB Protein
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IDBP-92596.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CHST15
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Protein Name
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carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000333947
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InnateDB Gene
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IDBG-92594 (CHST15)
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Protein Structure
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Function |
Sulfotransferase that transfers sulfate from 3'- phosphoadenosine 5'-phosphosulfate (PAPS) to the C-6 hydroxyl group of the GalNAc 4-sulfate residue of chondroitin sulfate A and forms chondroitin sulfate E containing GlcA-GalNAc(4,6-SO(4)) repeating units. It also transfers sulfate to a unique non- reducing terminal sequence, GalNAc(4SO4)-GlcA(2SO4)-GalNAc(6SO4), to yield a highly sulfated structure similar to the structure found in thrombomodulin chondroitin sulfate. May also act as a B- cell receptor involved in BCR ligation-mediated early activation that mediate regulatory signals key to B-cell development and/or regulation of B-cell-specific RAG expression; however such results are unclear in vivo. {ECO:0000269PubMed:11572857, ECO:0000269PubMed:12874280}.
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Subcellular Localization |
Golgi apparatus membrane {ECO:0000305PubMed:10749872}; Single-pass type II membrane protein {ECO:0000305PubMed:10749872}. Note=A small fraction may also be present at the cell surface, where it acts as a B-cell receptor.
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Disease Associations |
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Tissue Specificity |
Expressed in B-cell-enriched tissues but not in fetal or adult thymus. Expressed in fetal and adult spleen, lymph node, tonsil, bone marrow and peripheral leukocytes. Not expressed in T-cells. In pro-B, pre-B, and mature B-cell lines, it colocalizes with RAG1. {ECO:0000269PubMed:9754571}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0008146
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sulfotransferase activity
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GO:0050656
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3'-phosphoadenosine 5'-phosphosulfate binding
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GO:0050659
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N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000863
Sulfotransferase domain
IPR027417
P-loop containing nucleoside triphosphate hydrolase
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PFAM |
PF00685
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q7LFX5
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PhosphoSite |
PhosphoSite-Q7LFX5
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
51363
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UniGene |
Hs.731394
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RefSeq |
NP_056976
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HUGO |
HGNC:18137
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OMIM |
608277
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CCDS |
CCDS7638
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HPRD |
12203
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IMGT |
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EMBL |
AB011170
AB025341
AB062423
AF026477
AL683842
BC027908
BC050540
BC075813
CR749804
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GenPept |
AAC71691
AAH27908
AAH50540
AAH75813
BAA25524
BAA83686
BAB72145
CAH18664
CAI14442
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