InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: OAT

Summary

InnateDB Protein

IDBP-92637.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

OAT

Protein Name

ornithine aminotransferase

Synonyms

GACR; HOGA; OATASE; OKT;

Species

Homo sapiens

Ensembl Protein

ENSP00000357838

InnateDB Gene

IDBG-92635 (OAT)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Mitochondrion matrix.

Disease Associations

Hyperornithinemia with gyrate atrophy of choroid and retina (HOGA) [MIM:258870]: A disorder clinically characterized by a triad of progressive chorioretinal degeneration, early cataract formation, and type II muscle fiber atrophy. Characteristic chorioretinal atrophy with progressive constriction of the visual fields leads to blindness at the latest during the sixth decade of life. Patients generally have normal intelligence. {ECO:0000269PubMed:1612597, ECO:0000269PubMed:1737786, ECO:0000269PubMed:2793865, ECO:0000269PubMed:3375240, ECO:0000269PubMed:7668253, ECO:0000269PubMed:7887415}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.

Experimentally validated
Total	25 [view]
Protein-Protein	24 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004587	ornithine-oxo-acid transaminase activity
GO:0008483	transaminase activity
GO:0030170	pyridoxal phosphate binding

Biological Process

GO:0007601	visual perception
GO:0008652	cellular amino acid biosynthetic process
GO:0034214	protein hexamerization
GO:0034641	cellular nitrogen compound metabolic process
GO:0044281	small molecule metabolic process
GO:0055129	L-proline biosynthetic process