Version 5.4
Homo sapiens Protein: LHPP
Summary
InnateDB Protein IDBP-92697.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LHPP
Protein Name phospholysine phosphohistidine inorganic pyrophosphate phosphatase
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000357835
InnateDB Gene IDBG-92693 (LHPP)
Protein Structure
UniProt Annotation
Function Phosphatase that hydrolyzes imidodiphosphate, 3- phosphohistidine and 6-phospholysine. Has broad substrate specificity and can also hydrolyze inorganic diphosphate, but with lower efficiency (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:16430861}. Nucleus {ECO:0000269PubMed:16430861}.
Disease Associations
Tissue Specificity Expressed in brain, and at lower levels in liver and kidney. Detected in thyroid (at protein level). Expressed in liver, kidney and moderately in brain. {ECO:0000269PubMed:12801912, ECO:0000269PubMed:16430861}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0004427 inorganic diphosphatase activity
GO:0008969 phosphohistidine phosphatase activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0006796 phosphate-containing compound metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR006355 HAD-superfamily hydrolase, subfamily IIA, hypothetical 2
IPR006357 HAD-superfamily hydrolase, subfamily IIA
IPR023214 HAD-like domain
PFAM PF13344
PF00702
PF08282
PF13419
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H008
PhosphoSite PhosphoSite-Q9H008
TrEMBL
UniProt Splice Variant
Entrez Gene 64077
UniGene Hs.527748
RefSeq NP_071409
HUGO HGNC:30042
OMIM
CCDS CCDS7640
HPRD 17274
IMGT
EMBL AB049629 AK055532 AL391708 AL445237 AL513190 BC110344 BC113629 BC113631
GenPept AAI10345 AAI13630 AAI13632 BAB16411 BAG51532 CAH70377 CAH70378 CAH74011 CAI17295 CAI17296

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca