Version 5.4
Homo sapiens Protein: CSDC2
Summary
InnateDB Protein IDBP-9273.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CSDC2
Protein Name cold shock domain containing C2, RNA binding
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000302485
InnateDB Gene IDBG-9271 (CSDC2)
Protein Structure
UniProt Annotation
Function RNA-binding factor which binds specifically to the very 3'-UTR ends of both histone H1 and H3.3 mRNAs, encompassing the polyadenylation signal. Might play a central role in the negative regulation of histone variant synthesis in the developing brain (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=PIPPin-RNA complexes are located to the nucleus. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006397 mRNA processing
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR002059 Cold-shock protein, DNA-binding
IPR011129 Cold shock protein
IPR012340 Nucleic acid-binding, OB-fold
PFAM PF00313
PRINTS PR00050
PIRSF
SMART SM00357
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y534
PhosphoSite PhosphoSite-Q9Y534
TrEMBL
UniProt Splice Variant
Entrez Gene 27254
UniGene Hs.310893
RefSeq NP_055275
HUGO HGNC:30359
OMIM
CCDS CCDS14019
HPRD 15140
IMGT
EMBL AB027011 AL023553 AL834417 BC067113 CR456457
GenPept AAH67113 BAA84704 CAB46024 CAD39079 CAG30343

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca