Version 5.4
Homo sapiens Protein: ZRANB1
Summary
InnateDB Protein IDBP-92734.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZRANB1
Protein Name zinc finger, RAN-binding domain containing 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000352676
InnateDB Gene IDBG-92732 (ZRANB1)
Protein Structure
UniProt Annotation
Function Specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'- linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. May also modulate TNF-alpha signaling. {ECO:0000269PubMed:18281465, ECO:0000269PubMed:21834987, ECO:0000269PubMed:22157957, ECO:0000269PubMed:23827681}.
Subcellular Localization Cytoplasm. Nucleus. Note=Enriched in punctate localization in the cytoplasm.
Disease Associations
Tissue Specificity Widely expressed. {ECO:0000269PubMed:11463333}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
Experimentally validated
Total 34 [view]
Protein-Protein 34 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004221 ubiquitin thiolesterase activity
GO:0004843 ubiquitin-specific protease activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0070530 K63-linked polyubiquitin binding
Biological Process
GO:0007010 cytoskeleton organization
GO:0016055 Wnt signaling pathway
GO:0016477 cell migration
GO:0022604 regulation of cell morphogenesis
GO:0030177 positive regulation of Wnt signaling pathway
GO:0035523 protein K29-linked deubiquitination
GO:0070536 protein K63-linked deubiquitination
GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process
GO:1990168 protein K33-linked deubiquitination
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR001876 Zinc finger, RanBP2-type
IPR003323 Ovarian tumour, otubain
PFAM PF00641
PF02338
PRINTS
PIRSF
SMART SM00547
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UGI0
PhosphoSite PhosphoSite-Q9UGI0
TrEMBL
UniProt Splice Variant
Entrez Gene 54764
UniGene Hs.736102
RefSeq NP_060050
HUGO HGNC:18224
OMIM 611749
CCDS CCDS7642
HPRD 11738
IMGT
EMBL AJ252060 AK302810 AL731571 AL731577 AL832925 CH471066
GenPept BAG64010 CAB64449 CAH10620 CAH72159 CAI16103 EAW49252 EAW49253

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca