InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EDF1

Summary

InnateDB Protein

IDBP-92786.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EDF1

Protein Name

endothelial differentiation-related factor 1

Synonyms

EDF-1; MBF1;

Species

Homo sapiens

Ensembl Protein

ENSP00000224073

InnateDB Gene

IDBG-92784 (EDF1)

Protein Structure

UniProt Annotation

Function

Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. May function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism. {ECO:0000269PubMed:10567391, ECO:0000269PubMed:12040021, ECO:0000269PubMed:15112053, ECO:0000269PubMed:9813014}.

Subcellular Localization

Cytoplasm. Nucleus. Note=Also nuclear upon binding to NR5A1 and treatment of cells with TPA or forskolin.

Disease Associations

Tissue Specificity

Expressed in brain, liver, lung, kidney and heart (at protein level). Ubiquitously expressed. More abundant in heart, pancreas, liver, intestine and adipose tissues. {ECO:0000269PubMed:10567391, ECO:0000269PubMed:12040021, ECO:0000269PubMed:9813014}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0043565	sequence-specific DNA binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007275	multicellular organismal development
GO:0019216	regulation of lipid metabolic process
GO:0043388	positive regulation of DNA binding
GO:0045446	endothelial cell differentiation
GO:0045893	positive regulation of transcription, DNA-templated

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005669	transcription factor TFIID complex
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001387 Cro/C1-type helix-turn-helix domain
IPR010982 Lambda repressor-like, DNA-binding domain
IPR013729 Multiprotein bridging factor 1, N-terminal

PFAM

PF01381
PF13443
PF13413
PF08523

PRINTS

PIRSF

SMART

SM00530

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O60869