InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ADAM12

Summary

InnateDB Protein

IDBP-93038.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADAM12

Protein Name

ADAM metallopeptidase domain 12

Synonyms

ADAM12-OT1; CAR10; MCMP; MCMPMltna; MLTN; MLTNA;

Species

Homo sapiens

Ensembl Protein

ENSP00000357665

InnateDB Gene

IDBG-93032 (ADAM12)

Protein Structure

UniProt Annotation

Function

Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors (By similarity). {ECO:0000250}.

Subcellular Localization

Isoform 1: Cell membrane; Single-pass type I membrane protein.Isoform 2: Secreted.Isoform 3: Secreted {ECO:0000305}.Isoform 4: Secreted {ECO:0000305}.

Disease Associations

Tissue Specificity

Isoform 1 is expressed in placenta and skeletal, cardiac, and smooth muscle. Isoform 2 seems to be expressed only in placenta or in embryo and fetus. Both forms were expressed in some tumor cells lines. Not detected in brain, lung, liver, kidney or pancreas.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0005515	protein binding
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding
GO:0017124	SH3 domain binding

Biological Process

GO:0006508	proteolysis
GO:0007155	cell adhesion
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007520	myoblast fusion

Cellular Component

GO:0005576	extracellular region
GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000742 Epidermal growth factor-like domain
IPR001590 Peptidase M12B, ADAM/reprolysin
IPR001762 Blood coagulation inhibitor, Disintegrin
IPR002870 Peptidase M12B, propeptide
IPR006586 ADAM, cysteine-rich

PFAM

PF00008
PF01421
PF00200
PF01562
PF08516

PRINTS

PR00289

PIRSF

SMART

SM00181
SM00050
SM00608

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt