InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SP4

Summary

InnateDB Protein

IDBP-9306.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SP4

Protein Name

Sp4 transcription factor

Synonyms

HF1B; SPR-1;

Species

Homo sapiens

Ensembl Protein

ENSP00000222584

InnateDB Gene

IDBG-9304 (SP4)

Protein Structure

UniProt Annotation

Function

Binds to GT and GC boxes promoters elements. Probable transcriptional activator.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Abundant in brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	6 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003713	transcription coactivator activity
GO:0046872	metal ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0008016	regulation of heart contraction

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR007087 Zinc finger, C2H2
IPR015880 Zinc finger, C2H2-like

PFAM

PF00096

PRINTS

PIRSF

SMART

SM00355

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q02446

PhosphoSite

PhosphoSite-Q02446

TrEMBL

Q32M51

UniProt Splice Variant

Entrez Gene

6671

UniGene

Hs.88013

RefSeq

NP_003103

HUGO

HGNC:11209

OMIM

600540

CCDS

CCDS5373

HPRD

02764

IMGT

EMBL

AC004595 AK289728 BC109300 BC109301 CH471073 X68561

GenPept

AAI09301 AAI09302 BAF82417 CAA48563 EAW93733