InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: C10orf90

Summary

InnateDB Protein

IDBP-93107.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

C10orf90

Protein Name

chromosome 10 open reading frame 90

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000284694

InnateDB Gene

IDBG-93103 (C10orf90)

Protein Structure

UniProt Annotation

Function

Tumor suppressor that is required to sustain G2/M checkpoint after DNA damage. Mediates CDKN1A/p21 protein stability in a ubiquitin-independent manner (By similarity). May have a role in the assembly of primary cilia. {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:20844083}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:20844083}. Note=Localizes to the actin cytoskeleton in a proportion of cells. Colocalizes with centriolar acetylated tubulin.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0042826	histone deacetylase binding

Biological Process

GO:0006974	cellular response to DNA damage stimulus
GO:0007095	mitotic G2 DNA damage checkpoint
GO:0009411	response to UV
GO:0010212	response to ionizing radiation
GO:0030308	negative regulation of cell growth
GO:0050821	protein stabilization