Version 5.4
Homo sapiens Protein: FILIP1
Summary
InnateDB Protein IDBP-93117.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FILIP1
Protein Name filamin A interacting protein 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000359037
InnateDB Gene IDBG-93113 (FILIP1)
Protein Structure
UniProt Annotation
Function By acting through a filamin-A/F-actin axis, it controls the start of neocortical cell migration from the ventricular zone. May be able to induce the degradation of filamin-A (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity Moderately expressed in adult heart and brain. Weakly expressed in lung, skeletal muscle, ovary, testis, kidney, and fetal brain, and hardly detectable in liver, pancreas, spleen, and fetal liver. Within brain, moderate expression is found in amygdala and caudate nucleus. {ECO:0000269PubMed:10574462}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Protein Structure and Domains
PDB ID
InterPro IPR000533 Tropomyosin
IPR019131 Cortactin-binding protein-2, N-terminal
PFAM PF00261
PF12718
PF09727
PRINTS PR00194
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-Q7Z7B0
TrEMBL
UniProt Splice Variant
Entrez Gene 27145
UniGene Hs.696158
RefSeq
HUGO HGNC:21015
OMIM 607307
CCDS
HPRD 09533
IMGT
EMBL
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca