InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MKI67

Summary

InnateDB Protein

IDBP-93169.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MKI67

Protein Name

antigen identified by monoclonal antibody Ki-67

Synonyms

KIA; MIB-; MIB-1; PPP1R105;

Species

Homo sapiens

Ensembl Protein

ENSP00000357643

InnateDB Gene

IDBG-93167 (MKI67)

Protein Structure

UniProt Annotation

Function

Thought to be required for maintaining cell proliferation.

Subcellular Localization

Nucleus {ECO:0000269PubMed:22002106}. Nucleus, nucleolus {ECO:0000269PubMed:22002106}. Chromosome {ECO:0000269PubMed:22002106}. Note=Predominantly localized in the G1 phase in the perinucleolar region, in the later phases it is also detected throughout the nuclear interior, being predominantly localized in the nuclear matrix. In mitosis, it is present on all chromosomes.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.

Experimentally validated
Total	38 [view]
Protein-Protein	35 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008022	protein C-terminus binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006259	DNA metabolic process
GO:0007126	meiotic nuclear division
GO:0008283	cell proliferation
GO:0014070	response to organic cyclic compound
GO:0030212	hyaluronan metabolic process
GO:0031100	organ regeneration
GO:0034605	cellular response to heat

Cellular Component

GO:0000775	chromosome, centromeric region
GO:0000793	condensed chromosome
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0016020	membrane