Version 5.4
Homo sapiens Protein: MKI67
Summary
InnateDB Protein IDBP-93171.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MKI67
Protein Name antigen identified by monoclonal antibody Ki-67
Synonyms KIA; MIB-; MIB-1; PPP1R105;
Species Homo sapiens
Ensembl Protein ENSP00000357642
InnateDB Gene IDBG-93167 (MKI67)
Protein Structure
UniProt Annotation
Function Thought to be required for maintaining cell proliferation.
Subcellular Localization Nucleus {ECO:0000269PubMed:22002106}. Nucleus, nucleolus {ECO:0000269PubMed:22002106}. Chromosome {ECO:0000269PubMed:22002106}. Note=Predominantly localized in the G1 phase in the perinucleolar region, in the later phases it is also detected throughout the nuclear interior, being predominantly localized in the nuclear matrix. In mitosis, it is present on all chromosomes.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
Experimentally validated
Total 38 [view]
Protein-Protein 35 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0008283 cell proliferation
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR000253 Forkhead-associated (FHA) domain
IPR008984 SMAD/FHA domain
IPR012568 K167R
PFAM PF00498
PF08065
PRINTS
PIRSF
SMART SM00240
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P46013
PhosphoSite PhosphoSite-P46013
TrEMBL
UniProt Splice Variant
Entrez Gene 4288
UniGene Hs.80976
RefSeq NP_001139438
HUGO HGNC:7107
OMIM 176741
CCDS CCDS53588
HPRD 08902
IMGT
EMBL AL355529 AL390236 X65550 X65551 X94762
GenPept CAA46519 CAA46520 CAA64388 CAH73169

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca