Version 5.4
Homo sapiens Protein: LRRC26
Summary
InnateDB Protein IDBP-93178.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LRRC26
Protein Name leucine rich repeat containing 26
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000360597
InnateDB Gene IDBG-93176 (LRRC26)
Protein Structure
UniProt Annotation
Function Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Required for the conversion of BK alpha channels from a high-voltage to a low- voltage activated channel type in non-excitable cells. These are characterized by negative membrane voltages and constant low levels of calcium. {ECO:0000269PubMed:20613726, ECO:0000269PubMed:22547800}.
Subcellular Localization Cell membrane; Single-pass type I membrane protein. Cytoplasm, cytoskeleton. Note=Localizes to the cytoplasm when expressed at high levels. {ECO:0000269PubMed:15164053}.
Disease Associations
Tissue Specificity Isoform 1 is expressed highly in normal prostate and salivary gland, very weakly in colon, pancreas, and intestine, and not at all in other tissues. Isoform 1 is expressed highly in many cancer cell lines and in breast cancer, pancreatic cancer and colon cancer. Isoform 2 is expressed in cancer cell lines. {ECO:0000269PubMed:16585525, ECO:0000269PubMed:19250639}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0015459 potassium channel regulator activity
Biological Process
GO:0006811 ion transport
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0008076 voltage-gated potassium channel complex
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001611 Leucine-rich repeat
IPR003591 Leucine-rich repeat, typical subtype
PFAM PF00560
PF13504
PF13855
PRINTS
PIRSF
SMART SM00369
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q2I0M4
PhosphoSite PhosphoSite-Q2I0M4
TrEMBL
UniProt Splice Variant
Entrez Gene 389816
UniGene Hs.669977
RefSeq NP_001013675
HUGO HGNC:31409
OMIM 613505
CCDS CCDS35184
HPRD 18397
IMGT
EMBL AL929554 BC140911 DQ355157 EU588721
GenPept AAI40912 ABC79623 ACO90295 CAH72880

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca