InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RAP1GAP

Summary

InnateDB Protein

IDBP-93269.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAP1GAP

Protein Name

RAP1 GTPase activating protein

Synonyms

RAP1GA1; RAP1GAP1; RAP1GAPII; RAPGAP;

Species

Homo sapiens

Ensembl Protein

ENSP00000363897

InnateDB Gene

IDBG-93263 (RAP1GAP)

Protein Structure

UniProt Annotation

Function

GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state. {ECO:0000269PubMed:15141215}.

Subcellular Localization

Golgi apparatus membrane; Peripheral membrane protein.

Disease Associations

Tissue Specificity

Significant expression seen in the brain, kidney and pancreas. Abundant in the cerebral cortex and expressed at much lower levels in the spinal cord. Not detected in the lymphoid tissues. {ECO:0000269PubMed:9346962}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	25 [view]
Protein-Protein	24 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005096	GTPase activator activity
GO:0005515	protein binding
GO:0017016	Ras GTPase binding
GO:0030695	GTPase regulator activity
GO:0042803	protein homodimerization activity
GO:0046582	Rap GTPase activator activity

Biological Process

GO:0006184	GTP catabolic process
GO:0007165	signal transduction
GO:0032318	regulation of Ras GTPase activity
GO:0032854	positive regulation of Rap GTPase activity
GO:0050790	regulation of catalytic activity
GO:0051056	regulation of small GTPase mediated signal transduction