InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RAP1GAP

Summary

InnateDB Protein

IDBP-93273.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAP1GAP

Protein Name

RAP1 GTPase activating protein

Synonyms

RAP1GA1; RAP1GAP1; RAP1GAPII; RAPGAP;

Species

Homo sapiens

Ensembl Protein

ENSP00000363895

InnateDB Gene

IDBG-93263 (RAP1GAP)

Protein Structure

UniProt Annotation

Function

GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state. {ECO:0000269PubMed:15141215}.

Subcellular Localization

Golgi apparatus membrane; Peripheral membrane protein.

Disease Associations

Tissue Specificity

Significant expression seen in the brain, kidney and pancreas. Abundant in the cerebral cortex and expressed at much lower levels in the spinal cord. Not detected in the lymphoid tissues. {ECO:0000269PubMed:9346962}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	25 [view]
Protein-Protein	24 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity
GO:0030695	GTPase regulator activity

Biological Process

GO:0043547	positive regulation of GTPase activity
GO:0050790	regulation of catalytic activity
GO:0051056	regulation of small GTPase mediated signal transduction