InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DPYSL4

Summary

InnateDB Protein

IDBP-93350.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DPYSL4

Protein Name

dihydropyrimidinase-like 4

Synonyms

CRMP3; DRP-4; ULIP4;

Species

Homo sapiens

Ensembl Protein

ENSP00000339850

InnateDB Gene

IDBG-93348 (DPYSL4)

Protein Structure

UniProt Annotation

Function

Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0016787	hydrolase activity
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

Biological Process

GO:0006208	pyrimidine nucleobase catabolic process
GO:0007399	nervous system development
GO:0007411	axon guidance
GO:0048666	neuron development

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR006680 Amidohydrolase 1
IPR011059 Metal-dependent hydrolase, composite domain
IPR011778 Hydantoinase/dihydropyrimidinase

PFAM

PF01979

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-O14531

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AB006713 AL512622 BC136329 BC136330 CH471066 Y10976

GenPept

AAI36330 AAI36331 BAA21886 CAA71872 CAI12185 EAW49131 EAW49132 EAW49133 EAW49134 EAW49135 EAW49137 EAW49138

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1)

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca