InnateDB Protein
|
IDBP-93365.4
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
ENTPD8
|
Protein Name
|
ectonucleoside triphosphate diphosphohydrolase 8
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000360561
|
InnateDB Gene
|
IDBG-93363 (ENTPD8)
|
Protein Structure
|
|
Function |
Canalicular ectonucleoside NTPDase responsible for the main hepatic NTPDase activity. Ectonucleoside NTPDases catalyze the hydrolysis of gamma- and beta-phosphate residues of nucleotides, playing a central role in concentration of extracellular nucleotides. Has activity toward ATP, ADP, UTP and UDP, but not toward AMP. {ECO:0000269PubMed:16752921, ECO:0000269PubMed:17095758}.
|
Subcellular Localization |
Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
|
Molecular Function |
|
Biological Process |
GO:0009124
|
nucleoside monophosphate biosynthetic process
|
GO:0009133
|
nucleoside diphosphate biosynthetic process
|
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR000407
Nucleoside phosphatase GDA1/CD39
|
PFAM |
PF01150
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q5MY95
|
PhosphoSite |
PhosphoSite-Q5MY95
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
377841
|
UniGene |
Hs.512562
|
RefSeq |
NP_001028285
|
HUGO |
HGNC:24860
|
OMIM |
|
CCDS |
CCDS43913
|
HPRD |
16864
|
IMGT |
|
EMBL |
AY359088
AY430414
AY903953
AY903954
BC141810
BX322799
|
GenPept |
AAI41811
AAQ89446
AAR04374
AAW83515
AAW83516
CAM24777
|
|
|