Version 5.4
Homo sapiens Protein: MRPL41
Summary
InnateDB Protein IDBP-93490.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MRPL41
Protein Name mitochondrial ribosomal protein L41
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000360498
InnateDB Gene IDBG-93488 (MRPL41)
Protein Structure
UniProt Annotation
Function Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins. {ECO:0000269PubMed:16024796, ECO:0000269PubMed:16256947}.
Subcellular Localization Mitochondrion {ECO:0000269PubMed:16024796}.
Disease Associations
Tissue Specificity Present in kidney, liver, thymus and testis, and at lower level in brain and spleen (at protein level). {ECO:0000269PubMed:15547950}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
Experimentally validated
Total 34 [view]
Protein-Protein 34 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006412 translation
GO:0006915 apoptotic process
GO:0007049 cell cycle
Cellular Component
GO:0005739 mitochondrion
GO:0005762 mitochondrial large ribosomal subunit
GO:0030529 ribonucleoprotein complex
Protein Structure and Domains
PDB ID
InterPro IPR019189 Ribosomal protein L27/L41, mitochondrial
PFAM PF09809
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8IXM3
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 64975
UniGene
RefSeq NP_115866
HUGO HGNC:14492
OMIM 611846
CCDS CCDS7046
HPRD 14760
IMGT
EMBL AB051625 AL365502 AY232291 BC040035
GenPept AAH40035 AAP69986 BAB54952 CAI14583

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca