InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KNDC1

Summary

InnateDB Protein

IDBP-93575.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KNDC1

Protein Name

kinase non-catalytic C-lobe domain (KIND) containing 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000304437

InnateDB Gene

IDBG-93571 (KNDC1)

Protein Structure

UniProt Annotation

Function

Probable guanine nucleotide exchange factor (GEF).

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed specifically in the cerebral cortex. {ECO:0000269Ref.1}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0004674	protein serine/threonine kinase activity
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005088	Ras guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0001934	positive regulation of protein phosphorylation
GO:0006468	protein phosphorylation
GO:0007264	small GTPase mediated signal transduction
GO:0008150	biological_process
GO:0008152	metabolic process
GO:0021707	cerebellar granule cell differentiation
GO:0032318	regulation of Ras GTPase activity
GO:0043547	positive regulation of GTPase activity
GO:0048814	regulation of dendrite morphogenesis
GO:0050773	regulation of dendrite development
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0005575	cellular_component
GO:0005622	intracellular
GO:0030425	dendrite
GO:0032045	guanyl-nucleotide exchange factor complex
GO:0043025	neuronal cell body

Protein Structure and Domains

PDB ID

InterPro

IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
IPR011009 Protein kinase-like domain
IPR011019 KIND
IPR023578 Ras guanine nucleotide exchange factor domain

PFAM

PF00618
PF00617

PRINTS

PIRSF

SMART

SM00229
SM00147
SM00750

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q76NI1