InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CACNA1B

Summary

InnateDB Protein

IDBP-93623.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CACNA1B

Protein Name

calcium channel, voltage-dependent, N type, alpha 1B subunit

Synonyms

BIII; CACNL1A5; CACNN; Cav2.2;

Species

Homo sapiens

Ensembl Protein

ENSP00000360423

InnateDB Gene

IDBG-93621 (CACNA1B)

Protein Structure

UniProt Annotation

Function

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin- IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Isoform Alpha-1b-1 and isoform Alpha-1b-2 are expressed in the central nervous system, but not in skeletal muscle or aorta.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005245	voltage-gated calcium channel activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008022	protein C-terminus binding
GO:0008331	high voltage-gated calcium channel activity

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0006816	calcium ion transport
GO:0007268	synaptic transmission
GO:0007269	neurotransmitter secretion
GO:0007626	locomotory behavior
GO:0008016	regulation of heart contraction
GO:0008217	regulation of blood pressure
GO:0034765	regulation of ion transmembrane transport
GO:0048265	response to pain
GO:0051899	membrane depolarization
GO:0051924	regulation of calcium ion transport
GO:0055085	transmembrane transport
GO:0070509	calcium ion import
GO:0070588	calcium ion transmembrane transport
GO:0086010	membrane depolarization during action potential

Cellular Component

GO:0005886	plasma membrane
GO:0005891	voltage-gated calcium channel complex
GO:0016020	membrane
GO:0030425	dendrite
GO:0043025	neuronal cell body

Protein Structure and Domains

PDB ID

InterPro

IPR002048 EF-hand domain
IPR002077 Voltage-dependent calcium channel, alpha-1 subunit
IPR003915 Polycystic kidney disease type 2 protein
IPR005447 Voltage-dependent calcium channel, N-type, alpha-1 subunit
IPR005821 Ion transport domain
IPR013122 Polycystin cation channel, PKD1/PKD2
IPR014873 Voltage-dependent calcium channel, alpha-1 subunit, IQ domain

PFAM

PF00036
PF13202
PF13405
PF00520
PF08016
PF08763

PRINTS

PR00167
PR01433
PR01631

PIRSF

SMART

SM00054
SM01062

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt