InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TPBG

Summary

InnateDB Protein

IDBP-93686.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TPBG

Protein Name

trophoblast glycoprotein

Synonyms

5T4; 5T4AG; M6P1; WAIF1;

Species

Homo sapiens

Ensembl Protein

ENSP00000358765

InnateDB Gene

IDBG-93684 (TPBG)

Protein Structure

UniProt Annotation

Function

May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a- dependent LRP6 internalization. {ECO:0000269PubMed:22100263}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:24582434}; Single-pass type I membrane protein {ECO:0000269PubMed:24582434}.

Disease Associations

Tissue Specificity

Expressed by all types of trophoblasts as early as 9 weeks of development. Specific for trophoblastic cells except for amniotic epithelium. In adult tissues, the expression is limited to a few epithelial cell types but is found on a variety of carcinoma.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.

Experimentally validated
Total	27 [view]
Protein-Protein	27 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0007155

cell adhesion

Cellular Component

GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005887	integral component of plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000372 Leucine-rich repeat-containing N-terminal
IPR000483 Cysteine-rich flanking region, C-terminal
IPR001611 Leucine-rich repeat
IPR003591 Leucine-rich repeat, typical subtype

PFAM

PF01462
PF01463
PF00560
PF13504
PF13855

PRINTS

PIRSF

SMART

SM00013
SM00082
SM00369

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q13641