InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CALY

Summary

InnateDB Protein

IDBP-93698.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CALY

Protein Name

calcyon neuron-specific vesicular protein

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000357543

InnateDB Gene

IDBG-93690 (CALY)

Protein Structure

UniProt Annotation

Function

Interacts with clathrin light chain A and stimulates clathrin self-assembly and clathrin-mediated endocytosis. {ECO:0000269PubMed:16595675}.

Subcellular Localization

Cytoplasmic vesicle membrane; Single-pass membrane protein. Cell membrane; Single-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed in the pyramidal cells of the prefrontal cortex, in hippothalamus and in caudate nucleus. No expression in spleen. Up-regulated in the prefrontal cortex of schizophrenic patients with nearly twice the levels of non- schizophrenics. {ECO:0000269PubMed:12622665}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0032051	clathrin light chain binding

Biological Process

GO:0006897	endocytosis
GO:0007212	dopamine receptor signaling pathway
GO:0045807	positive regulation of endocytosis
GO:0048268	clathrin coat assembly

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0030659	cytoplasmic vesicle membrane
GO:0031410	cytoplasmic vesicle